Synthesis and analgesic activity evaluation of some agmatine derivatives.

نویسندگان

Hongxia He

Mengjia Liu

Zhibing Zheng

Ying Liu

Junhai Xiao

Ruibin Su

Chun Hu

Jin Li

Song Li

چکیده

A series of N,N'-disubstituted-2-nitroethene-1,1-diamine and N,N'-disubstituted- N''-cyanoguanidine derivatives were prepared and evaluated for in vivo analgesic activity. The blood brain barrier (BBB) VolSurf model was used to predict the BBB permeation profiles of our synthesized compounds. Some compounds show both remarkable analgesic activity and good BBB permeation profiles, and these compounds might be developed for treatment of opioid tolerance and dependence.

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